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Maximum intensity projection of a PET/CT with choline: Note the physiologic accumulation in the liver, pancreas, kidney, bladder, spleen, bone marrow and salivary glands. Because of its involvement in biologic processes, several medical imaging techniques have been developed to monitor relative concentration and kinetics of choline in different diseases.

Radiolabeling one of the nitrogen methyl groups on choline with carbon-11 allows it to be used as a tracer in PET imaging studies.

Choline hydroxide is one of the class of phase transfer catalysts that are used to carry the hydroxide ion into organic systems, and, therefore, is considered a strong base.

It is the least-costly phase transfer catalyst, and is used as an effective method of stripping photoresists in circuit boards.

All three have published an "Adequate Intake" value, discussed below.

The European Union's food safety authority says there are no Recommended Daily Intakes in the EU and "no indications of inadequate choline intakes available in the EU".

The cation appears in the head groups of phosphatidylcholine and sphingomyelin, two classes of phospholipid that are abundant in cell membranes.

Carbon-11 choline has found more success in cancer systems imaging.

Choline is a precursor for the synthesis of phospholipids in our cells.

The Australian, New Zealand, and European Union national nutrition bodies note there have been no reports of choline deficiency in the general population.

The USA joins these three in not publishing a Recommended Dietary Allowance (RDA), due to lack of consensus evidence.




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